Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness.

ABSTRACT:

Aims

Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness.

Methods and results

A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire

SUBMITTER: Back M 

PROVIDER: S-EPMC9242081 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature