Sex differences in associations of comorbidities with incident cardiovascular disease: focus on absolute risk.

ABSTRACT:

Aim

To examine sex differences in associations of obesity, type-2 diabetes, hypertension, and atrial fibrillation (AF) with incident cardiovascular disease (CVD), focusing on absolute risk measures.

Methods and results

We included a total of 7994 individuals (mean age 49.1 years; 51.2% women) without prior CVD from the PREVEND (Prevention of Renal and Vascular End-stage Disease) cohort with a median follow-up of 12.5 years. Using Poisson regression, we calculated the increase in absolute as well as relative CVD risk associated with a comorbidity using incidence rate differences (IRD = IR_comorbidity-IR_{no-comorbidity}) and incidence rate ratios (IRR = IR_comorbidity/IR_{no-comorbidity}), respectively. Sex differences were presented as wom

SUBMITTER: Dronkers J 

PROVIDER: S-EPMC9242082 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature