High fibrosis-4 index predicts the new onset of ischaemic heart disease during a 10-year period in a general population.

ABSTRACT:

Aims

The fibrosis-4 (FIB-4) index, calculated using age, platelet count, and levels of aspartate aminotransferase and alanine aminotransferase, is a non-invasive indicator for the detection of liver fibrosis. Advanced hepatic fibrosis is associated with morbidity and mortality in patients with non-alcoholic fatty liver disease. However, the relationship between liver fibrosis and the development of ischaemic heart disease (IHD) has not fully been addressed.

Methods and results

We investigated the association between the FIB-4 index and the new onset of IHD during a 10-year period in a general population of subjects who received annual health examinations (n = 28 990). After exclusion of subjects with missing data and those with a history of IHD at baseline, a total of

SUBMITTER: Higashiura Y 

PROVIDER: S-EPMC9242084 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature