Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes.

ABSTRACT:

Introduction

Maternal SARS-CoV-2 infection during pregnancy is associated with adverse pregnancy outcomes and can have effects on the placenta, even in the absence of severe disease or vertical transmission to the fetus. This study aimed to evaluate histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy.

Methods

We performed a study of 45 pregnant participants from the Generation C prospective cohort study at the Mount Sinai Health System in New York City. We compared histologic features and the expression of 48 immune and trophoblast genes in placentas delivered from 15 SARS-CoV-2 IgG antibody positive and 30 IgG SARS-CoV-2 antibody negative mothers. Statistical analyses were performed using Fisher's exact tests, Spearman correlati

SUBMITTER: Lesseur C 

PROVIDER: S-EPMC9242701 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature