Radiopharmaceutical Quality Control Considerations for Accelerator-Produced Actinium Therapies.

ABSTRACT: Background: Alpha-particle-emitting radiotherapies are of great interest for the treatment of disseminated cancer. Actinium-225 (²²⁵Ac) produces four α-particles through its decay and is among the most attractive radionuclides for use in targeted radiotherapy applications. However, supply issues for this isotope have limited availability and increased cost for research and translation. Efforts have focused on accelerator-based methods that produce ²²⁵Ac in addition to long-lived ²²⁷Ac. Objective: The authors investigated the impact of ²²⁵Ac/²²⁷Ac material in the radiolabeling and radiopharmaceutical quality control evaluation of a DOTA chelate-conjugated peptide under good manufacturing practices. The author

SUBMITTER: Abou DS 

PROVIDER: S-EPMC9242709 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature