ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.

ABSTRACT: Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals^1,2. A subfamily, palmitic acid esters of hydroxy stearic acids (PAHSAs), are anti-inflammatory and anti-diabetic^1,3. Humans and mice with insulin resistance have lower PAHSA levels in subcutaneous adipose tissue and serum¹. PAHSA administration improves glucose tolerance and insulin sensitivity and reduces inflammation in obesity, diabetes and immune-mediated diseases^1,4-7. The enzyme(s) responsible for FAHFA biosynthesis in vivo remains unknown. Here we identified adipose triglyceride lipase (ATGL, also known as patatin-like phospholipase domain containing 2 (PNPLA2)) as a candidate biosynthetic enzyme for FAHFAs 

SUBMITTER: Patel R 

PROVIDER: S-EPMC9242854 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature