Study of surface modification strategies to create glassy carbon-supported, aptamer-based sensors for continuous molecular monitoring.

ABSTRACT: Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes

SUBMITTER: Pellitero MA 

PROVIDER: S-EPMC9242903 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature