Inulin-g-poly-D,L-lactide, a sustainable amphiphilic copolymer for nano-therapeutics.

ABSTRACT: Cancer therapies started to take a big advantage from new nanomedicines on the market. Since then, research tried to better understand how to maximize efficacy while maintaining a high safety profile. Polyethylene glycol (PEG), the gold standard for nanomedicines coating design, is a winning choice to ensure a long circulation and colloidal stability, while in some cases, patients could develop PEG-directed immunoglobulins after the first administration. This lead to a phenomenon called accelerated blood clearance (ABC effect), and it is correlated with clinical failure because of the premature removal of the nanosystem from the circulation by immune mechanism. Therefore, alternatives to PEG need to be found. Here, looking at the backbone structural analogy, the hydrophilicity, flexibility

SUBMITTER: Sardo C 

PROVIDER: S-EPMC9242920 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature