Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment.

ABSTRACT:

Objective

To assess associations of single and combined exposures to lead and stress during different stages of pregnancy with offspring neurodevelopment.

Methods

We measured prenatal lead (maternal blood-lead in early-pregnancy and umbilical-cord-blood-lead) and maternal stress levels in Shanghai-Birth-Cohort from 2013 to 2016. Maternal stress was assessed using Center-for-Epidemiological-Studies-Depression-Scale and Self-Rating-Anxiety-Scale during mid-pregnancy. The Ages-Stages-Questionnaires-3 (at 6/12-months-of-age) and Bayley-III (at 24-months-of-age) were both used to assess neurodevelopment.

Results

A total of 2132 mother-child pairs with both prenatal lead and stress measurements were included. The geometric-means of blood-lead in early-pregnancy and cord-blo

SUBMITTER: Guo X 

PROVIDER: S-EPMC9243049 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature