Activated-memory T cells influence naive T cell fate: a noncytotoxic function of human CD8 T cells.

ABSTRACT: T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population - i.e., within the naïve or memory pool; however, less is known about the cross-talk between T cell subsets. Here, we tested whether memory T cells interact with and influence surrounding naïve T cells. We report that human naïve CD8 T cells (T_N) undergo phenotypic and transcriptional changes in the presence of autologous activated-memory CD8 T cells (T_Mem). Following in vitro co-culture with activated central memory cells (T_CM), ~3% of the T_N acquired activation/memory canonical markers (CD45RO and CD95) in an

SUBMITTER: Sasaki K 

PROVIDER: S-EPMC9243096 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature