Six genetically linked mutations in the CD36 gene significantly delay the onset of Alzheimer's disease.

ABSTRACT: The risk of Alzheimer's disease (AD) has a strong genetic component, also in the case of late-onset AD (LOAD). Attempts to sequence whole genome in large populations of subjects have identified only a few mutations common to most of the patients with AD. Targeting smaller well-characterized groups of subjects where specific genetic variations in selected genes could be related to precisely defined psychological traits typical of dementia is needed to better understand the heritability of AD. More than one thousand participants, categorized according to cognitive deficits, were assessed using 14 psychometric tests evaluating performance in five cognitive domains (attention/working memory, memory, language, executive functions, visuospatial functions). CD36 was selected as a gene previously

SUBMITTER: Sery O 

PROVIDER: S-EPMC9243110 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature