Magnesium stable isotope composition, but not concentration, responds to obesity and early insulin-resistant conditions in minipig.

ABSTRACT: Hypomagnesemia is frequently associated with type 2 diabetes and generally correlates with unfavorable disease progression, but the magnesium status in pre-diabetic conditions remains unclear. Here, the magnesium metabolism is scrutinized in a minipig model of obesity and insulin resistance by measuring variations of the metallome-the set of inorganic elements-and the magnesium stable isotope composition in six organs of lean and obese minipigs raised on normal and Western-type diet, respectively. We found that metallomic variations are most generally insensitive to lean or obese phenotypes. The magnesium stable isotope composition of plasma, liver, kidney, and heart in lean minipigs are significantly heavier than in obese minipigs. For both lean and obese minipigs, the magnesium isotope c

SUBMITTER: le Goff S 

PROVIDER: S-EPMC9243132 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature