Defining the Impact of Family History on Detection of High-grade Prostate Cancer in a Large Multi-institutional Cohort.

ABSTRACT:

Background

The risk of high-grade prostate cancer, given a family history of cancer, has been described in the general population, but not among men selected for prostate biopsy in an international cohort.

Objective

To estimate the risk of high-grade prostate cancer on biopsy based on a family history of cancer.

Design, setting, and participants

This is a multicenter study of men undergoing prostate biopsy from 2006 to 2019, including 12 sites in North America and Europe. All sites recorded first-degree prostate cancer family histories; four included more detailed data on the number of affected relatives, second-degree relatives with prostate cancer, and breast cancer family history.

Outcomes measurements and statistical analysis

Multivariable logistic regressi

SUBMITTER: Clements MB 

PROVIDER: S-EPMC9243191 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature