CD155 promotes radioresistance and malignancy of esophageal cancer by regulating Hippo-YAP pathway.

ABSTRACT: The expression of CD155 has been observed to increase in various human cancers, but its role in the development of esophageal cancer (EC) is unclear. Radiotherapy is one of the primary therapeutic options for EC. However, radioresistance is still a severe issue in EC treatment. In this study, Oncomine database mining, immunohistochemistry, and survival analysis showed that higher expression of CD155 in patients with EC than in healthy controls. In vitro and in vivo, we found for the first time that irradiation increased the expression of CD155 in EC cells. CD155 knockdown inhibited cell proliferation and migration and tumor formation, and significantly increased radiosensitivity in EC. The in vivo model with high CD155 expression significantly promoted the proliferation and migration of EC

SUBMITTER: Xin H 

PROVIDER: S-EPMC9243211 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature