Tumor-Specific CD4⁺ T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4^- T Cells.

ABSTRACT: Cytotoxic CD8⁺ T cells are the main focus of efforts to understand anti-tumor immunity and immunotherapy. The adoptive transfer of tumor-reactive cytotoxic CD8⁺ T lymphocytes expanded and differentiated in vitro has long been considered the primary strategy in adaptive anti-tumor immunity, however, the majority of the transferred tumor antigen-specific CD8⁺ T cells differentiated into CD39⁺CD69⁺ exhausted progenies, limiting its effects in repressing tumor growth. Contrarily, less attention has been addressed to the role of CD4⁺ T cells during tumorigenesis. Using a mouse model of metastatic melanoma, we found that transferring tumor-specific CD4⁺ T cells into recipients induces substantial regression of th

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9243303 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature