Expanding the Malaria Antibody Toolkit: Development and Characterisation of <i>Plasmodium falciparum</i> RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies.

ABSTRACT: Malaria, an infection caused by apicomplexan parasites of the genus Plasmodium, continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in excess of 600,000. Considerable progress has been made to reduce malaria burden in endemic countries in the last two decades. However, parasite and mosquito resistance to frontline chemotherapies and insecticides, respectively, highlights the continuing need for the development of safe and effective vaccines. Here we describe the development of recombinant human antibodies to three target proteins from Plasmodium falciparum: reticulocyte binding protein homologue 5 (PfRH5), cysteine-rich protective antigen (PfCyRPA), and circumsporozoite protein (PfCSP). All three prote

SUBMITTER: Nacer A 

PROVIDER: S-EPMC9243361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature