Real-life short-term effectiveness of anti-osteoporotic treatments: a longitudinal cohort study.

ABSTRACT:

Introduction

Randomized clinical trials have shown that anti-osteoporotic treatments can increase bone mineral density (BMD) and reduce the incidence of fragility fractures. However, data on the real-life effectiveness of anti-osteoporotic medications are still scarce.

Methods

We conducted a cohort study on women at high risk of fracture. We retrieved clinical and densitometric data from the DeFRA database, which derives from the DeFRA tool, a web-based fracture risk assessment tool. Multivariable Cox regression survival models were employed to analyze the effectiveness of different anti-osteoporotic drugs on fracture. In sensitivity analyses, we conducted 1:1 propensity score matching analyses.

Results

Data on 50,862 women were available. Among these, 3574 individual

SUBMITTER: Adami G 

PROVIDER: S-EPMC9243369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature