Laterality and Sex Differences of Human Lateral Habenula Afferent and Efferent Fiber Tracts.

ABSTRACT:

Introduction

The lateral habenula (LHb) is an epithalamic nucleus associated with negative valence and affective disorders. It receives input via the stria medullaris (SM) and sends output via the fasciculus retroflexus (FR). Here, we use tractography to reconstruct and characterize this pathway.

Methods

Multi-shell human diffusion magnetic resonance imaging (dMRI) data was obtained from the human connectome project (HCP) (n = 20, 10 males) and from healthy controls (n = 10, 6 males) scanned at our institution. We generated LHb afferents and efferents using probabilistic tractography by selecting the pallidum as the seed region and the ventral tegmental area as the output target.

Results

We were able to reconstruct the intended streamlines

SUBMITTER: Hitti FL 

PROVIDER: S-EPMC9243380 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature