Necroptosis-Related Genes Associated With Immune Activity and Prognosis of Colorectal Cancer.

ABSTRACT: This study aims at screening out the key necroptosis-related genes in colorectal cancer and elucidating the role of necroptosis-related genes in the immune activity and prognosis of colorectal cancer (CRC). The CRC patients' data were downloaded from The Cancer Genome Atlas (TCGA). The non-negative matrix factorization method was applied to identify new molecular subgroups. Survival analysis and single sample Gene Set Enrichment Analysis were performed to determinate the differences in the overall survival time and immune status of the subgroups. Prognostic model was constructed on the basis of univariate Cox regression and LASSO analysis. Functional analyses were used to explore the potential mechanisms. Based on prognostic related necroptosis genes, we identify two molecular subgr

SUBMITTER: Peng X 

PROVIDER: S-EPMC9243386 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature