Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development.

ABSTRACT: Depression is the most common type of neuropsychiatric illness and has increasingly become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 has dramatically increased the incidence of depression and has significantly increased the burden of mental health care worldwide. Since full remission of the clinical symptoms of depression has not been achieved with current treatments, there is a constant need to discover new compounds that meet the major clinical needs. Recently, the roles of sigma receptors, especially the sigma-1 receptor subtype, have attracted increasing attention as potential new targets and target-specific drugs due to their translocation property that produces a broad spectrum of biological functions. Even clinical first-line antidepressants

SUBMITTER: Ren P 

PROVIDER: S-EPMC9243434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature