Identification of NAD⁺ Metabolism-Derived Gene Signatures in Ovarian Cancer Prognosis and Immunotherapy.

ABSTRACT: Background: Nicotinamide adenine dinucleotide (NAD⁺) has emerged as a critical regulator of cell signaling and survival pathways, affecting tumor initiation and progression. In this study it was investigated whether circulating NAD⁺ metabolism-related genes (NMRGs) could be used to predict immunotherapy response in ovarian cancer (OC) patients. Method: In this study, NMRGs were comprehensively examined in OC patients, three distinct NMRGs subtypes were identified through unsupervised clustering, and an NAD⁺-related prognostic model was generated based on LASSO Cox regression analysis and generated a risk score (RS). ROC curves and an independent validation cohort were used to assess the model's accuracy. A GSEA enrichment analysis was performe

SUBMITTER: Lin L 

PROVIDER: S-EPMC9243463 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature