Increased ATP2A1 Predicts Poor Prognosis in Patients With Colorectal Carcinoma.

ABSTRACT: Colorectal cancer is one of the most common malignant tumors in the digestive system. Traditional diagnosis and treatment methods have not significantly improved the overall survival of patients. In this study, we explored the value of ATP2A1 as a biomarker in predicting the prognosis of colorectal cancer patients. We used the TCGA database to reveal the relationship between ATP2A1 mRNA level and prognosis, methylation, and immune invasion in colorectal cancer. The results showed that the expression of ATP2A1 was increased in colorectal cancer. The overall survival of patients with high expression of ATP2A1 was significantly lower than patients with low expression of ATP2A1. Cox regression analysis showed that high expression of ATP2A1 was an indep

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9243465 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature