Effects of Sarcolemmal Background Ca²⁺ Entry and Sarcoplasmic Ca²⁺ Leak Currents on Electrophysiology and Ca²⁺ Transients in Human Ventricular Cardiomyocytes: A Computational Comparison.

ABSTRACT: The intricate regulation of the compartmental Ca²⁺ concentrations in cardiomyocytes is critical for electrophysiology, excitation-contraction coupling, and other signaling pathways. Research into the complex signaling pathways is motivated by cardiac pathologies including arrhythmia and maladaptive myocyte remodeling, which result from Ca²⁺ dysregulation. Of interest to this investigation are two types of Ca²⁺ currents in cardiomyocytes: 1) background Ca²⁺ entry, i.e., Ca²⁺ transport across the sarcolemma from the extracellular space into the cytosol, and 2) Ca²⁺ leak from the sarcoplasmic reticulum (SR) across the SR membrane into the cytosol. Candidates for the ion channels underlying background Ca²⁺ entry and S

SUBMITTER: Streiff ME 

PROVIDER: S-EPMC9243544 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature