Designing Adjuvant Formulations to Promote Immunogenicity and Protective Efficacy of <i>Leptospira</i> Immunoglobulin-Like Protein A Subunit Vaccine.

ABSTRACT: The leptospirosis burden on humans, especially in high-risk occupational groups and livestock, leads to public health and economic problems. Leptospirosis subunit vaccines have been under development and require further improvement to provide complete protection. Adjuvants can be used to enhance the amplitude, quality, and durability of immune responses. Previously, we demonstrated that LMQ adjuvant (neutral liposomes containing monophosphoryl lipid A (MPL) and Quillaja saponaria derived QS21 saponin) promoted protective efficacy of LigAc vaccine against Leptospira challenge. To promote immunogenicity and protective efficacy of the subunit vaccines, three alternative adjuvants based on neutral liposomes or squalene-in-water emulsion were evaluated in this study. LQ and LQuil

SUBMITTER: Techawiwattanaboon T 

PROVIDER: S-EPMC9243587 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature