Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort

ABSTRACT: The coagulation system can be assessed by the thrombin generation (TG) assay, and increased TG peak height, endogenous thrombin potential (ETP), and velocity index are associated with an increased risk of thrombosis. Obesity had been reported to increase TG and is associated with dyslipidemia, which also predisposes to atherosclerotic cardiovascular disease (CVD). However, the effect of the blood lipid profile on TG has not been studied extensively. To gain more insight into the associations of TG, body mass index (BMI) and lipid profile, we studied TG in relation to these parameters in a large Italian population cohort, the Moli-sani study (N = 22,546; age ≥ 35 years; 48% men). TG was measured in plasma samples collected at the enrollment of subjects in the Moli-sani study. TG was trigger

SUBMITTER: de Laat-Kremers R 

PROVIDER: S-EPMC9243635 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature