Development of an immunogen containing CD4⁺/CD8⁺ T-cell epitopes for the prophylaxis of tegumentary leishmaniasis.

ABSTRACT: Tegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological agent. The inefficiency of control measures, such as high toxicity and costs of current treatments and the lack of effective immunoprophylactic strategies, makes the development of vaccines indispensable and imminent. In this light, the present work developed a gene encoding multiple T-cell (CD4⁺/CD8⁺) epitope, derived from conserved proteins found in Leishmania species and associated with TL, to generate a chimeric protein (rMEP/TL) and compose a vaccine formulation. For this, six T-cell epitopes were selected by immunoinformatics approaches from proteins present in the amastigote stage and associated with host-parasite interaction

SUBMITTER: de Andrade Ferraz I 

PROVIDER: S-EPMC9244519 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature