The genetic and evolutionary determinants of COVID-19 susceptibility.

ABSTRACT: Devastating pandemics, such as that due to COVID-19, can provide strong testimony to our knowledge of the genetic and evolutionary determinants of infectious disease susceptibility and severity. One of the most remarkable aspects of such outbreaks is the stunning interindividual variability observed in the course of infection. In recent decades, enormous progress has been made in the field of the human genetics of infectious diseases, and an increasing number of human genetic factors have been reported to explain, to a great extent, the observed variability for a large number of infectious agents. However, our understanding of the cellular, molecular, and immunological mechanisms underlying such disparities between individuals and ethnic groups, remains very limited. Here, we discuss recen

SUBMITTER: Kerner G 

PROVIDER: S-EPMC9244541 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature