Development and Validation of a Prediction Model for Perinatal Arterial Ischemic Stroke in Term Neonates.

ABSTRACT:

Importance

Perinatal arterial ischemic stroke (PAIS) is a focal brain injury in term neonates that is identified postnatally but is presumed to occur near the time of birth. Many pregnancy, delivery, and fetal factors have been associated with PAIS, but early risk detection is lacking; thus, targeted treatment and prevention efforts are currently limited.

Objective

To develop and validate a diagnostic risk prediction model that uses common clinical factors to predict the probability of PAIS in a term neonate.

Design, setting, and participants

In this diagnostic study, a prediction model was developed using multivariable logistic regression with registry-based case data collected between January 2003, and March 2020, from the Alberta Perinatal Stroke Project, Canadian

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC9244611 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature