Helios Expression Is Downregulated on CD8⁺ Treg in Two Mouse Models of Lupus During Disease Progression.

ABSTRACT: T-cell-mediated autoimmunity reflects an imbalance in this compartment that is not restored by tolerogenic immune cells, e.g., regulatory T cells or tolerogenic dendritic cells (tolDCs). Although studies into T-cell equilibrium have mainly focused on regulatory CD4⁺FoxP3⁺ T cells (CD4⁺ Tregs), recent findings on the lesser known CD8⁺ Tregs (CD44⁺CD122⁺Ly49⁺) have highlighted their non-redundant role in regulating lupus-like disease and their regulatory phenotype facilitated by the transcription factor Helios in mice and humans. However, there are still remaining questions about Helios regulation and dynamics in different autoimmune contexts. Here, we show the absence of CD8⁺ Tregs in two lupus-prone mur

SUBMITTER: Paris-Munoz A 

PROVIDER: S-EPMC9244697 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature