Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease.

ABSTRACT: The retina, as part of the central nervous system (CNS), can be the perfect target for in vivo, in situ, and noninvasive neuropathology diagnosis and assessment of therapeutic efficacy. It has long been established that several age-related brain changes are more pronounced in Alzheimer's disease (AD). Nevertheless, in the retina such link is still under-explored. This study investigates the differences in the aging of the CNS through the retina of 3× Tg-AD and wild-type mice. A dedicated optical coherence tomograph imaged mice's retinas for 16 months. Two neural networks were developed to model independently each group's ages and were then applied to an independent set containing images from both groups. Our analysis shows a mean absolute error of 0.875±1.1 × 10^-2 and 1.1

SUBMITTER: Guimaraes P 

PROVIDER: S-EPMC9244797 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature