Non-linear and non-additive associations between the pregnancy metabolome and birthweight.

ABSTRACT:

Background

Birthweight is an indicator of fetal growth and environmental-related alterations of birthweight have been linked with multiple disorders and conditions progressing into adulthood. Although a few studies have assessed the association between birthweight and the totality of exogenous exposures and their downstream molecular responses in maternal urine and cord blood; no prior research has considered a) the maternal serum prenatal metabolome, which is enriched for hormones, and b) non-linear and synergistic associations among exposures.

Methods

We measured the maternal serum metabolome during pregnancy using an untargeted metabolomics approach and birthweight for gestational age (BWGA) z-score in 410 mother-child dyads enrolled in the PRogramming of Intergenerationa

SUBMITTER: Colicino E 

PROVIDER: S-EPMC9244839 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature