Ontology highlight
ABSTRACT:
SUBMITTER: Blasiak A
PROVIDER: S-EPMC9244889 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Blasiak Agata A Truong Anh T L ATL Remus Alexandria A Hooi Lissa L Seah Shirley Gek Kheng SGK Wang Peter P Chye De Hoe H Lim Angeline Pei Chiew APC Ng Kim Tien KT Teo Swee Teng ST Tan Yee-Joo YJ Allen David Michael DM Chai Louis Yi Ann LYA Chng Wee Joo WJ Lin Raymond T P RTP Lye David C B DCB Wong John Eu-Li JE Tan Gek-Yen Gladys GG Chan Conrad En Zuo CEZ Chow Edward Kai-Hua EK Ho Dean D
NPJ digital medicine 20220630 1
IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated ...[more]