Gender dimorphism in survival of patients with lymph node metastasis of bladder cancer.

ABSTRACT:

Background

The effect of gender on the prognosis of bladder cancer (BCa) in different metastatic sites is insufficiently understood. We aimed to assess the impact and potential mechanisms of a combination of gender dimorphism and BCa metastasis sites on the risk of death.

Methods

Independent predictors of overall survival and cancer-specific survival were analyzed after stratification by gender and metastasis sites from the Surveillance, Epidemiology, and End Results database. Furthermore, gender-differentially expressed genes (DEGs) and function-enriched annotations for patients with lymph node metastasis (LNM) were identified from The Cancer Genome Atlas (TCGA) database. A gender-associated signature was constructed in TCGA and validated in the IMvigor210 trial, and the ma

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9244946 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature