Non-destructive vacuum-assisted measurement of lung elastic modulus.

ABSTRACT: In living tissues, mechanical stiffness and biological function are intrinsically linked. Alterations in the stiffness of tissues can induce pathological interactions that affect cellular activity and tissue function. Underlying connections between tissue stiffness and disease highlights the importance of accurate quantitative characterizations of soft tissue mechanics, which can improve our understanding of disease and inform therapeutic development. In particular, accurate measurement of lung mechanical properties has been especially challenging due to the anatomical and mechanobiological complexities of the lung. Discrepancies between measured mechanical properties of dissected lung tissue samples and intact lung tissues in vivo has limited the ability to accurately characterize integra

SUBMITTER: Chen J 

PROVIDER: S-EPMC9245063 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature