PUNISHER rs12318065 C>A transversion: a putative somatic driver mutation for poor prognosis in colon cancer.

ABSTRACT:

Objective

Colon cancer (CC) remains one of the leading causes of cancer death worldwide. Several mutations/polymorphisms have been implicated in CC development and/or progression. The role of the recently identified variants related to the long non-coding RNAs (lncRNAs) family has not yet been fully uncovered. In this sense, we aimed to explore the association between the lncRNA PUNISHER rs12318065 variant and the CC risk and/or prognosis.

Methods

A total of 408 CC (paired 204 cancer/non-cancer) tissues were genotyped using the TaqMan allelic discrimination assay.

Results

"A" variant was associated with higher susceptibility to develop CC under heterozygote (A/C vs. C/C: OR = 1.39, 95%CI = 1.09-2.17, P=0.002), homozygote (A/A vs. C/C: OR = 2.63, 95%CI = 1.51-4.58, P=0

SUBMITTER: Shaheen S 

PROVIDER: S-EPMC9245078 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature