Mixed Ligand Mononuclear Copper(II) Complex as a Promising Anticancer Agent: Interaction Studies with DNA/HSA, Molecular Docking, and In Vitro Cytotoxicity Studies.

ABSTRACT: The isolated copper(II) complex [CuL(o-phen)]·H₂O (1) [H₂L = o-HO-C₆H₄C(H)=N-C₆H₄-SH-o, o-phen = 1,10-phenanthroline] was structurally characterized using single-crystal X-ray crystallography. 1 in CH₃CN at liquid nitrogen temperature displayed a characteristic monomeric X-band electron paramagnetic resonance spectrum having a tetragonal character with g _∥ = 2.1479 and g _⊥ = 2.0691 and A _∥ ≈ 18.0 mT and A _⊥ ≤ 3.9 mT, respectively. 1 showed a strong binding affinity toward calf thymus DNA as reflected from its intrinsic binding constant (K _b = 7.88 × 10⁵ M^-1

SUBMITTER: Paliwal K 

PROVIDER: S-EPMC9245097 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature