Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions.

ABSTRACT:

Background

Subcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on functional recovery after focal white matter injury.

Methods

A focal corpus callosum lesion was induced by stereotactic injection of N⁵-(1-iminoethyl)-L-ornithine in mice. Fasudil (10 mg/kg) or vehicle was administered daily for 2 weeks, starting one day after lesion induction. Resting-state functional connectivity and grid walk performance were studied longitudinally, and lesion volumes were determined at one month.

Results

Resting-state interhemispheric functional connectivity significantly recovered between days 1 and 14 in the fasudil gr

SUBMITTER: Aykan SA 

PROVIDER: S-EPMC9245195 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature