Ferroptosis-related long non-coding RNA signature predicts the prognosis of bladder cancer.

ABSTRACT:

Background

Ferroptosis is an iron-dependent programmed cell death modality that may have a tumor-suppressive function. Therefore, regulating ferroptosis in tumor cells could serve as a novel therapeutic approach. This article focuses on ferroptosis-associated long non-coding RNAs (lncRNAs) and their potential application as a prognostic predictor for bladder cancer (BCa).

Methods

We retrieved BCa-related transcriptome information and clinical information from the TCGA database and ferroptosis-related gene sets from the FerrDb database. Least absolute shrinkage and selection operator regression (LASSO) and Cox regression models were used to identify and develop predictive models and validate the model accuracy. Finally, we explored the inter-regulatory relationships between f

SUBMITTER: Hou J 

PROVIDER: S-EPMC9245204 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature