Population-based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015-2018.

ABSTRACT:

Objective

This study aims to describe clinical findings and determine the medium-term survival of congenital zika syndrome (CZS) suspected cases.

Methods

A retrospective cohort study using routine register-based linked data. It included all suspected cases of CZS born in Brazil from January 1, 2015, to December 31, 2018, and followed up from birth until death, 36 months, or December 31, 2018, whichever came first. Latent class analysis was used to cluster unconfirmed cases into classes with similar combinations of anthropometry at birth, imaging findings, maternally reported rash, region, and year of birth. Kaplan-Meier curves were plotted, and Cox proportional hazards models were fitted to determine mortality up to 36 months.

Results

We followed 11,850 suspected case

SUBMITTER: Paixao ES 

PROVIDER: S-EPMC9245223 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature