White matter pathology in alzheimer's transgenic mice with chronic exposure to low-level ambient fine particulate matter.

ABSTRACT:

Background

Air pollution, especially fine particulate matter (PM), can cause brain damage, cognitive decline, and an increased risk of neurodegenerative disease, especially alzheimer's disease (AD). Typical pathological findings of amyloid and tau protein accumulation have been detected in the brain after exposure in animal studies. However, these observations were based on high levels of PM exposure, which were far from the WHO guidelines and those present in our environment. In addition, white matter involvement by air pollution has been less reported. Thus, this experiment was designed to simulate the true human world and to discuss the possible white matter pathology caused by air pollution.

Results

6 month-old female 3xTg-AD mice were divided into exposure and control g

SUBMITTER: Chen TF 

PROVIDER: S-EPMC9245233 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature