Delayed Infiltration of Peripheral Monocyte Contributes to Phagocytosis and Transneuronal Degeneration in Chronic Stroke.

ABSTRACT:

Background

Mononuclear phagocytes, including monocyte-derived macrophages (MDMs) and microglia, contribute to infarct development as well as tissue repair in the postischemic brain. Here, we identify the origin and function of MDMs in the brain during poststroke repair processes.

Methods

Adult mice were subjected to transient middle cerebral artery occlusion. Longitudinal brain atrophy and secondary degeneration were evaluated during acute to recovery phases of stroke. Adoptive transfer of GFP+ splenocytes into asplenic mice was used to distinguish MDMs from resident microglia. Fluorescence beads were injected into stroked animals to examine phagocytic function.

Results

Progressive atrophy and neuronal degeneration in remote regions were observed in chronic stroke, wh

SUBMITTER: Park KW 

PROVIDER: S-EPMC9245247 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature