Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus.

ABSTRACT:

Background

Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely relieved with neurosurgical approaches, since effective and targeted pharmacological tools are still lacking. The carbonic anhydrase inhibitor, acetazolamide (AZE), may be employed to treat elevated ICP. However, its effectiveness is questioned, its location of action unresolved, and its tolerability low. Here, we determined the efficacy and mode of action of AZE in the rat .

Methods

We employed in vivo approaches including ICP and cerebrospinal fluid secretion measurements in anaesthetized rats and telemetric monitoring of ICP and blood pressure in awake rats in combination with ex vivo choroidal radioisotope flux assays an

SUBMITTER: Barbuskaite D 

PROVIDER: S-EPMC9245291 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature