Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment.

ABSTRACT: The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein subfractions and metabolites after breast cancer treatment, aiming to determine the long-term effect of different treatment modalities. Further, we investigated the prognostic value of treatment-induced changes in breast cancer-specific and overall 10-year survival. In this study, serum samples from breast cancer patients (n = 250) were collected repeatedly before and after radiotherapy, and serum metabolites and lipoprotein subfractions were quantified by NMR spectroscopy. Longitudinal changes were assessed by univariate and multivariate data analysis methods applica

SUBMITTER: Giskeodegard GF 

PROVIDER: S-EPMC9245384 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature