Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patients.

ABSTRACT:

Background

Procalcitonin (PCT) and C-Reactive Protein (CRP) are useful biomarkers to differentiate bacterial from viral or fungal infections, although the association between them and co-infection or mortality in COVID-19 remains unclear.

Methods

The study represents a retrospective cohort study of patients admitted for COVID-19 pneumonia to 84 ICUs from ten countries between (March 2020-January 2021). Primary outcome was to determine whether PCT or CRP at admission could predict community-acquired bacterial respiratory co-infection (BC) and its added clinical value by determining the best discriminating cut-off values. Secondary outcome was to investigate its association with mortality. To evaluate the main outcome, a binary logistic regression was performed. The area under

SUBMITTER: Carbonell R 

PROVIDER: S-EPMC9245395 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature