CD73-Adenosine A₁R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP₃-Ca²⁺/DAG-PKC Signaling Pathway.

ABSTRACT: Alcohol-related liver fibrosis (ALF) is a form of alcohol-related liver disease (ALD) that generally occurs in response to heavy long-term drinking. Ecto-5'-nucleotidase (NT5E), also known as CD73, is a cytomembrane protein linked to the cell membrane via a GPI anchor that regulates the conversion of extracellular ATP to adenosine. Adenosine and its receptors are important regulators of the cellular response. Previous studies showed that CD73 and adenosine A1 receptor (A₁R) were important in alcohol-related liver disease, however the exact mechanism is unclear. The aim of this study was to elucidate the role and mechanism of the CD73-A₁R axis in both a murine model of alcohol and carbon tetrachloride (CCl₄) induced ALF and in an in vitro model

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9245432 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature