Analysis of Hepatic Lipid Metabolism and Immune Function During the Development of Collagen-Induced Arthritis.

ABSTRACT: The liver is essential for metabolic and immune functions and has been linked to systemic inflammatory diseases. However, the role of the liver is still elusive during the development of rheumatoid arthritis (RA), although there have been indeed some reports. We used label-free quantitative proteomics and experimental verification in this study to reveal the hepatic lipid metabolism and immune function during collagen-induced arthritis (CIA) development. The proteomics results revealed that the role of the liver differs in different phases of CIA rats. In terms of specific performance, hepatic lipid metabolism, which is primarily concerned with cholesterol, triacylglycerol, and phospholipid, was significantly influenced in the CIA induction phase, whereas the immune function, which include

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9245434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature