Molecular Spectrum, Ethnic and Geographical Distribution of Thalassemia in the Southern Area of Hainan, China.

ABSTRACT:

Background

Thalassemia is one of the most common genetic diseases in southern China. Accurate population frequency data regarding the occurrence and distribution of thalassemia are important for designing appropriate prevention strategies for thalassemia. This study aims to reveal the molecular spectrum, ethnic and geographical distribution of thalassemia in the southern area of Hainan Province, China.

Methods

A total of 9813 suspected carriers of thalassemia were screened for genetic analysis by using the PCR-reverse dot blot hybridization method targeting three known deletions of α-thalassemias (--^SEA, -α^3.7, and -α^4.2), three nondeletional mutations of α-thalassaemias (α^CS, α^QS, and α^WS) and the 17 most com

SUBMITTER: Yu Y 

PROVIDER: S-EPMC9245522 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature