Properties of 2-locus genealogies and linkage disequilibrium in temporally structured samples.

ABSTRACT: Archeogenetics has been revolutionary, revealing insights into demographic history and recent positive selection. However, most studies to date have ignored the nonrandom association of genetic variants at different loci (i.e. linkage disequilibrium). This may be in part because basic properties of linkage disequilibrium in samples from different times are still not well understood. Here, we derive several results for summary statistics of haplotypic variation under a model with time-stratified sampling: (1) The correlation between the number of pairwise differences observed between time-staggered samples (πΔt) in models with and without strict population continuity; (2) The product of the linkage disequilibrium coefficient, D, between ancient and modern samples, which is a measure of hapl

SUBMITTER: Biddanda A 

PROVIDER: S-EPMC9245597 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature