Microbiome-associated human genetic variants impact phenome-wide disease risk.

ABSTRACT: Human genetic variation associates with the composition of the gut microbiome, yet its influence on clinical traits remains largely unknown. We analyzed the consequences of nearly a thousand gut microbiome-associated variants (MAVs) on phenotypes reported in electronic health records from tens of thousands of individuals. We discovered and replicated associations of MAVs with neurological, metabolic, digestive, and circulatory diseases. Five significant MAVs in these categories correlate with the relative abundance of microbes down to the strain level. We also demonstrate that these relationships are independently observed and concordant with microbe by disease associations reported in case-control studies. Moreover, a selective sweep and population differentiation impacted some disease-li

SUBMITTER: Markowitz RHG 

PROVIDER: S-EPMC9245617 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature