Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome.

ABSTRACT: Mitochondria, a highly metabolically active organelle, have been shown to play an essential role in regulating innate immune function. Mitochondrial Ca²⁺ uptake via the mitochondrial Ca²⁺ uniporter (MCU) is an essential process regulating mitochondrial metabolism by targeting key enzymes involved in the tricarboxylic acid cycle (TCA). Accumulative evidence suggests MCU-dependent mitochondrial Ca²⁺ signaling may bridge the metabolic reprogramming and regulation of immune cell function. However, the mechanism by which MCU regulates inflammation and its related disease remains elusive. Here we report a critical role of MCU in promoting phagocytosis-dependent activation of NLRP3 (nucleotide-binding domain, leucine-rich repeat containing family, pyrin domain-con

SUBMITTER: Dong H 

PROVIDER: S-EPMC9245629 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature